Correction: Zika virus has oncolytic activity against glioblastoma stem cells

نویسندگان

  • Zhe Zhu
  • Matthew J. Gorman
  • Lisa D. McKenzie
  • Jiani N. Chai
  • Christopher G. Hubert
  • Briana C. Prager
  • Estefania Fernandez
  • Justin M. Richner
  • Rong Zhang
  • Chao Shan
  • Eric Tycksen
  • Xiuxing Wang
  • Pei-Yong Shi
  • Michael S. Diamond
  • Jeremy N. Rich
  • Milan G. Chheda
چکیده

Correction: Zika virus has oncolytic activity against glioblastoma stem cells Zhe Zhu, Matthew J. Gorman, Lisa D. McKenzie, Jiani N. Chai, Christopher G. Hubert, Briana C. Prager, Estefania Fernandez, Justin M. Richner, Rong Zhang, Chao Shan, Eric Tycksen, Xiuxing Wang, Pei-Yong Shi, Michael S. Diamond, Jeremy N. Rich, and Milan G. Chheda Vol. 214, No. 10, October 2017. https://doi.org/10.1084/jem.20171093

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Oncolytic herpes simplex virus-based strategies: toward a breakthrough in glioblastoma therapy

Oncolytic viruses (OV) are a class of antitumor agents that selectively kill tumor cells while sparing normal cells. Oncolytic herpes simplex virus (oHSV) has been investigated in clinical trials for patients with the malignant brain tumor glioblastoma for more than a decade. These clinical studies have shown the safety of oHSV administration to the human brain, however, therapeutic efficacy of...

متن کامل

Experimental therapies: gene therapies and oncolytic viruses. - PubMed - NCBI

Glioblastoma is the most common and aggressive primary brain tumor in adults. Over the past three decades, the overall survival time has only improved by a few months, therefore novel alternative treatment modalities are needed to improve clinical management strategies. Such strategies should ultimately extend patient survival. At present, the extensive insight into the molecular biology of gli...

متن کامل

Immunovirotherapy for the treatment of glioblastoma

We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleuk...

متن کامل

Using Cystine Knot Proteins as a Novel Approach to Retarget Oncolytic Measles Virus

Modified measles virus (MV) has effective oncolytic activity preclinically and is currently being investigated in clinical trials for various types of cancer. We investigated the use of cystine knot proteins (CKPs) to direct MV activity. CKPs are short polypeptides that bind their targets with high affinity. We used a CKP that binds αvβ3, αvβ5, and α5β1 integrins with single-digit nanomolar aff...

متن کامل

Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model.

Glioblastoma (World Health Organization grade IV) is an aggressive adult brain tumor that is inevitably fatal despite surgery, radiation, and chemotherapy. Treatment failures are attributed to combinations of cellular heterogeneity, including a subpopulation of often-resistant cancer stem cells, aberrant vasculature, and noteworthy immune suppression. Current preclinical models and treatment st...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 214  شماره 

صفحات  -

تاریخ انتشار 2017